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Literature summary extracted from

  • Miyagi, K.; Kaneshima, M.; Kawakami, J.; Nakada, F.; Petryka, Z.J.; Watson, C.J.
    Uroporphyrinogen I synthetase from human erythrocytes: Separation, purification, and properties of isoenzymes (1979), Proc. Natl. Acad. Sci. USA, 76, 6172-6176.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.61 36000
-
 gel filtration, fraction A and B Homo sapiens
2.5.1.61 38000
-
 1 * 38000, SDS-PAGE, B1 Homo sapiens
2.5.1.61 39500
-
 1 * 39500, SDS-PAGE, B2 and B3 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.61 porphobilinogen Homo sapiens
-
 ?
-
 ?
2.5.1.61 porphobilinogen Bos taurus
-
 ?
-
 ?
2.5.1.61 porphobilinogen Cereibacter sphaeroides
-
 ?
-
 ?
2.5.1.61 porphobilinogen Spinacia oleracea
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.61 Bos taurus
-
-
-
2.5.1.61 Cereibacter sphaeroides
-
-
-
2.5.1.61 Homo sapiens
-
-
-
2.5.1.61 Spinacia oleracea
-
 spinach
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.61 3 isoenzymes Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.61 callus tissue Bos taurus
-
2.5.1.61 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.61 additional information
-
-
 Homo sapiens
2.5.1.61 additional information
-
-
 Cereibacter sphaeroides

Storage Stability

EC Number Storage Stability Organism
2.5.1.61 purified enzyme loses its activity when it is frozen Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Homo sapiens uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Bos taurus uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Cereibacter sphaeroides uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Spinacia oleracea uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Homo sapiens hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Bos taurus hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Cereibacter sphaeroides hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Spinacia oleracea hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 porphobilinogen
-
 Homo sapiens ?
-
 ?
2.5.1.61 porphobilinogen
-
 Bos taurus ?
-
 ?
2.5.1.61 porphobilinogen
-
 Cereibacter sphaeroides ?
-
 ?
2.5.1.61 porphobilinogen
-
 Spinacia oleracea ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.61 monomer
-
 Cereibacter sphaeroides
2.5.1.61 monomer 1 * 38000, SDS-PAGE, B1 Homo sapiens
2.5.1.61 monomer 1 * 39500, SDS-PAGE, B2 and B3 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.5.1.61 porphobilinogen deaminase
-
 Homo sapiens
2.5.1.61 porphobilinogen deaminase
-
 Cereibacter sphaeroides
2.5.1.61 UPGI-S
-
 Homo sapiens
2.5.1.61 uroporphyrinogen I synthase
-
 Homo sapiens